Talking Biotech · episode 372
As Gods: A Moral History of the Genetic Age - Matthew Cobb Listen
Just because we can, does it mean that we should? Technology is developing so fast and enables so many new opportunities, but is there reason to occasionally pause and consider broader implications? Prof.
Talking Biotech · episode 371
The Genomes of Parasites - Dr. Jessie Kissinger Listen
Parasites are a massive threat to human and animal health, underlying a significant number of important diseases.
Talking Biotech · episode 370
Cancer Misinformation - Dr. Skyler Johnson Listen
As lifespan increases due to prevention and treatment of infectious disease and heart disorders, long-term issues like cancer become more prevalent.
Talking Biotech · episode 369
Livestock, Climate Change, and Attacks on a Scientist - Dr. Frank Mitloehner Listen
Dr. Frank Mitloener is an expert in the contributions of livestock to climate change. He is a researcher that studies ways to mitigate the greenhouse gases from ruminant digestion, and a trusted expert in outreach to ensure the implementation of new strategies.
Talking Biotech · episode 368
A Gene-Edited Vaccine Against Malaria - Dr. Stefan Kappe Listen
Malaria is a deadly, mosquito-vectored disease in areas of the Developing World. Intensive efforts have resulted in few effective prophylactic or therapeutic practices or products that are without serious limitations.
Talking Biotech · episode 367
Seralini's Lumpy Rats - Ten Years Later Listen
Ten years ago a scientific paper claimed definitive evidence linking genetic engineering to tumors. The study by Giles-Eric Seralini and his team at CRIIGEN stunned the world, and it was amplified through social and traditional media.
Talking Biotech · episode 366
New Therapeutics for Novel Problems through Collaboration - Dr. Betsy O'neill Listen
How can collaboration bring new technology to those that need it, faster? Dr. Linda O'Neill, VP of External Innovation at Horizon Therapeutics describes how strategic partnerships can speed the development and deployment of new therapeutics, particularly for autoimmune disorders and potential treatments for rare disease.
Talking Biotech · episode 365
The Long COVID HERV Connection - Dr. Claudia Matteucci Listen
Human endogenous retroviruses (HERVs) are ancient viruses found in our genomes, remnants of long-past infections.
Talking Biotech · episode 364
Purple Tomatoes and Health - Dr. Cathie Martin Listen
The purple compounds in fruits and vegetables associate with the perception of health and flavor. Prof.
Talking Biotech · episode 363
Rapid Detection of Sexually Transmitted Infections with Microfluidics - Dr. Anna Dixon Listen
Sexually transmitted infections, once thought to be low frequency events, are staging a comeback. Dr.
Talking Biotech · episode 362
The Gut-Brain Axis: What it is, associated problems and new therapies. Nancy Thornberry Listen
Research is showing a more intimate association between the digestive system and the brain, a bi-directional sensing and signaling network that directs digestive physiology.
Talking Biotech · episode 361
Precision Insect Control with Gene Editing Listen
Insects inflict tremendous human casualty and massive losses in agriculture. For more than half a century Sterile Insect Technique has been implemented to crash invasive or dangerous populations by damaging insect genetics and releasing them into target populations.
Talking Biotech · episode 360
Update on Animal Gene Editing Listen
Amazing innovations in animal gene editing have the promise to streamline agriculture, with benefits for agricultural producers, consumers and the environment.
Talking Biotech · episode 359
Creating Targeted Antibodies in Single Cells Listen
Antibodies are one line of adaptive immune response, responding to new antigens that may represent threats.
Talking Biotech · episode 358
Extending Health and Life, Starting with Dogs Listen
Dogs are an excellent model to study the genetics and mechanisms of aging. Loyal CEO Celine Halioua describes how genetic variation between breeds leads to specific effects on lifespan and "healthspan", and how new therapeutics might enrich and extend their lives.
Talking Biotech · episode 357
Optimizing Animal Microbiomes Listen
The microbiome is a population of bacteria, fungi, protists and viruses that inhabit a specific environment.
Talking Biotech · episode 356
Glyphosate in Breast Milk? Eco-Modernism Listen
This episode has two parts. In the first part lactation specialist Dr. Shelley McGuire discusses the new paper that claims to have found glyphosate in breast milk.
Talking Biotech · episode 355
Stool-Based Detection of Colon Cancer Listen
Colorectal cancer is one of the most deadly cancers in the industrialized world. However, dangerous malignancies occur after multiple committed genetic steps at the cellular level that happen over years.
Talking Biotech · episode 354
Microalgae: Factories for Improved Polymers Listen
Modern life has benefitted from the development of polymers that can be fashioned into everything from car parts, to children's toys, to medical devices.
Talking Biotech · episode 353
CAR-T Therapies to Reverse Cardiac Fibrosis Listen
Injury to heart tissue results in non-functional scar tissue that compromises cardiac function. A new approach combines targeted lipid nanoparicles and mRNAs to reprogram immune cells to seek and destroy the pathogenic fibroblasts that limit heart function.
Talking Biotech · episode 352
352 - Prions and Chronic Wasting Disease Listen
Chronic wasting disease is an increasingly common prion-based disease of deer and other cervids. Dr. Sandra Pritzkow describes the disease, it's transmission, and efforts to mitigate its spread.
Talking Biotech · episode 351
351 - Biotech, Pesticides, Toxicology and Food Listen
There is abundant conversation about pesticides and food, especially in social media. Unfortunately, there is little understanding about regulation, dosage, tolerances and toxicity.
Talking Biotech · episode 350
Methylation of DNA, Relationship to Disease Listen
Methylation is the addition of a small methyl group to specific bases of the DNA helix. Addition of a methyl group can change how the DNA blueprint is accessed and expressed.
Talking Biotech · episode 349
Addressing the Issue of Scientific Reproducibility Listen
Trust in science is predicated on independent reproducibility of research results. Perceived breakdowns in reproducibility have gained much recent attention, and it is up to the scientific community to devise new mechanisms to help ensure methods and results are complete and transparent.
Talking Biotech · episode 348
The Human Protein Atlas Listen
Proteins are the central catalytic and structural components of cells, and ultimately are at the center of cellular function.
Talking Biotech · episode 347
New Drugs that Repair Broken Genes Listen
Many diseases do not have cures, yet have a foundation in deleterious genomic mutations. Dietrich Stephan of NewBase describes a novel custom drug design platform that shows amazing potential in animal models, and seeks to directly reverse currently untreatable disease.
Talking Biotech · episode 346
An Owner's Manual for Your Brain Listen
In the age of an internet full of false information, how do we tell the real from the fictitious? Jon Guy introduces his new book, Thinking Straight- an owner's manual to the mind.
Talking Biotech · episode 345
Update on Self-Limiting Mosquitoes Listen
Mosquitoes are the world's most deadly insect, vectoring dozens of bloodborne diseases. Oxitec has been revising "sterile insect" techniques classically used in mosquito control with modern technologies that are more precise.
Talking Biotech · episode 344
New Drugs Targeting Dangerous Cholesterol Listen
Specific modifications of cholesterol appear to be central in heart disease, stroke and other disorders.
Talking Biotech · episode 343
Breeding the Next Amazing Apple Listen
Apples are a fruit favorite. What are modern breeders doing to create the next generation of superior fruits, that offer flavors for consumers and sustainability traits for farmers? Dr.
Talking Biotech · episode 342
Biological Plasticity, Bioelectricity, and Limb Regeneration Listen
Dr. Michael Levin of Tufts University discusses his laboratory's eclectic research programs that may be changing the way we think about animal development.
Talking Biotech · episode 341
Consumer Sentiment and Gene Editing Listen
Scientists say that gene editing will have profound positive impacts in medicine and agriculture. But what do consumers think? Today's Talking Biotech Podcast talks to agricultural economist Dr.
Talking Biotech · episode 340
Stopping Bleeding with Algal-Based Polymers Listen
Catastrophic bleeding is a cause of death after a wide variety of wounds in humans and other animals.
Talking Biotech · episode 339
Fungal Toxins in Food Listen
Mother Nature has created some of the world's most carcinogenic compounds. These natural fungal products are present on many commodity crops, and have profound impacts in the developing nations.
Talking Biotech · episode 338
Plastics and Fuels from Camelina Listen
Camelina is a mustard-family plant that may be genetically engineered to create a wide variety of important products, from plastics to jet fuel.
Talking Biotech · episode 337
Endogenous Retroviruses and Disease, Dr. Arvinda Nath Listen
Our genomes carry a massive amount of integrated viral DNA from infections in our ancestors. New evidence shows that they may be reactivated and drive cancer and neurological disorders.
Talking Biotech · episode 336
Evaluating Scientific Claims - Melanie Trecek-King Listen
The world's information is available to us at our fingertips. How do we recognize good sources and evaluate scientific claims? Melanie Trecek-King describes her tool kit for critical thinking.
Talking Biotech · episode 335
Resetting the Table with Dr. Robert Paarlberg Listen
Dr. Robert Paarlberg discusses his book, "Resetting the Table - Straight Talk About the Food We Grow and Eat".
Talking Biotech · episode 334
Biotech and Tick Vectored Disease Listen
Ticks are important disease vectors, spreading Lyme Disease and other human pathogens. New technology permits improved functional genetic research as well as creates a basis for genetic engineering strategies to limit populations or control disease vectoring.
Talking Biotech · episode 333
Plant Viruses / X Files Science Listen
Dr. Anne Simon describes viral threats to plant biology, and discusses how scientists have harnessed viruses to solve problems in agriculture.
Talking Biotech · episode 332
New Therapies for HERV-Based Disease Listen
Expression from Human Endogenous Retroviruses (HERVs) has been liked to Multiple Sclerosis and Amyotrophic Lateral Sclerosis (ALS) and other neurological diseases.
Talking Biotech · episode 331
Talking Biotech Podcast Changes and Future Listen
New sponsorship will improve the listener experience. Here are some of the changes you'll see with this opportunity.
Talking Biotech · episode 330
Avocado Genetics and Improvement Listen
The avocado is a nutritious and delicious fruit. Today's episode discusses its history, domestication, breeding priorities and future.
Talking Biotech · episode 329
Hollywood and the Percy Schmeiser Story Listen
The story of Percy Schmeiser is a well known tale of big biotech against the little farmer from rural Saskatchewan.
Talking Biotech · episode 328
The Importance of Telling Ag’s Story Listen
One of the criticisms of farmers is that they fail to engage the public to show what they do. It is understandable, their days are busy, competition is stiff, and farming selects for folks that shun the spotlight.
Talking Biotech · episode 327
Attacking Disease by Targeting Proteins Listen
Many diseases are rooted in the incorrect accumulation of proteins that regulate key cellular processes.
Talking Biotech · episode 326
Update on Transgenic (“GMO”) Chestnut Listen
The American Chestnut used to dominate Appalachian forests, but declined after a fungal disease was introduced to North America in the early 1900’s.
Talking Biotech · episode 325
Is Biotechnology Just New Colonialism? Listen
Two unusually parallel articles emerged this week, both claiming that modern ag technology (as they say, “GMO”) is just another arm of colonial control of the Developing World.
Talking Biotech · episode 324
Wine Flavor: Merging Grape and Yeast Genomes Listen
Wine is a fermented beverage that has been enjoyed for millennia. While many may feel that the grapes used produce the flavors in the wine, a substantial contribution comes from the yeast and specialized bacteria that performs feats of biochemistry on the components lent by the grape itself.
Talking Biotech · episode 323
Cindy’s Gift to End Glioblastoma Listen
At the early age of 47 Cindy Lee Graham lost her battle with glioblastoma. Glioblastoma is an insidious cancer of the brain and central nervous system that slowly robs its victims of critical faculties, with a very low survival rate.
Talking Biotech · episode 322
Gender Equity in the Pharmaceutical Industry Listen
The executive ranks of the pharmaceutical industry are populated with a clear over representation of older males.
Talking Biotech · episode 321
The Challenges of Growing Plants in Space Listen
Sustained space travel and colonization will depend on the ability to grow food in extra-terrestrial environments.
Talking Biotech · episode 320
Tiredness: Time for DNA Repair! Listen
We all know the feeling of tiredness, but what causes the urge to sleep? Prof. Lior Appelbaum discusses the link between sleepiness and DNA damage, as sensed through the accumulation of a protein known as PARP1.
Talking Biotech · episode 319
Reprogramming T-Cells for Immunotherapies Listen
T Cells are the body’snatural defenders against pathogens. In the past they have been reprogrammed to recognize specific surface antigens of cancer cells to attack and destroy them.
Talking Biotech · episode 318
Breeding Future Olives Listen
Olives have a prominent role in the production of aromatic healthy culinary oils and brined olives for the table.
Talking Biotech · episode 317
Insulin from Synthetic Biology Listen
Thirty million Americans depend on daily doses of insulin to stay alive. This small protein hormone is responsible for the regulation of blood sugar, and plays a key role in all aspects of physiology, as well as long-term effects on health.
Talking Biotech · episode 316
What We Can Learn from Ancient DNA Listen
How can analysis of DNA isolated from old, preserved organisms, bones, or tissues tell us about life today? Dr.
Talking Biotech · episode 315
Integrated Molecular Strategies in Combating Disease Listen
New strategies in gene therapy are integrating multiple modern techniques to take on contemporary challenging diseases, such as solid-tumor cancers.
Talking Biotech · episode 314
Genetic Counseling in the Biotech Era Listen
Genetic counselors play a critical role from pre-natal guidance to lifelong expertise in managing genetically-based disorders.
Talking Biotech · episode 313
Rediscovery of New Cancer Drugs Listen
Drug pipelines are thick with novel compounds that may have an effect on our most insidious diseases.
Talking Biotech · episode 312
Evidence that Modern Birds are Dinosaurs Listen
The classical assumption was that the modern dinosaur lineage led directly to today’s reptiles. However, a growing suite of evidence has shown that modern birds more closely emulate prehistoric creatures.
Talking Biotech · episode 311
Debunking Jeffrey Smith Listen
We must be dedicated to fighting back against false information in food and medicine. Jeffery Smith is a personality with no scientific training that has used disinformation to taint an important public discussion on biotechnology for over 25 years.
Talking Biotech · episode 310
Influencing a Conversation with a #ScienceHug Listen
In this week of technical failures and personal challenges, this week’s podcast investigates the merits of civil conversation.
Talking Biotech · episode 309
Relax and Enjoy Your Food Listen
There is no such thing as bad food, it is just bad diets, so says Craig Good. Various life events caused him to rethink his relationship with food, and a keen skepticism led him to carefully evaluate the mistakes we make, the myths we accept, and the potential reasons we have an epidemic of diet-related illness and an internet packed with fad diets.
Talking Biotech · episode 308
Misinformation and GMOs Listen
How does misinformation about genetically engineered crops (GMOs) start and how do we correct it? These are questions asked by Prof.
Talking Biotech · episode 307
Glyphosate Residues and Dietary Exposure Listen
The herbicide glyphosate has been used for decades, with increased use paralleling the adoption of genetically engineered crops.
Talking Biotech · episode 306
Florida’s COVID Response / Long COVID Listen
Today’s podcast features two interviews about COVID19. The first is an interview with Florida Commissioner of Agriculture Nikki Fried.
Talking Biotech · episode 305
Early Cancer Detection with Liquid Biopsy Listen
Many cancers are much more curable if detected early. However, the current suite of detection methods are slow, expensive and can’t detect a problem until it is advanced.
Talking Biotech · episode 304
Last Minute Guests! Listen
Yay for gremlins! Technical difficulties precluded the planned podcast, but that didn’t stop two good interviews from materializing a the last minute.
Talking Biotech · episode 303
Activating Suites of Plant Genes with Cas9 Listen
The role of Cas9 as an editing/deletion nuclease has been well established, but can it be used to turn genes on? Dr.
Talking Biotech · episode 302
COVID19 Detection in Masks and Wearables Listen
COVID19 is the spectrum of pathologies caused by the SARS-CoV2 virus. While the pandemic moves well into its second year, the importance of detection in populations cannot be overstated.
Talking Biotech · episode 301
Virus Resistant Cassava in Kenya Listen
Cassava is a staple for one in ten people on earth, grown mostly by small famers tending a few acres.
Talking Biotech · episode 300
The Battle to Teach Science Listen
Episode 300 is guest-hosted by Ally Kennedy. She interviews Dr. Kevin Folta about the obstacles to communicating science over the last decade.
Talking Biotech · episode 299
Revisiting Huber’s Claims Listen
He jet-sets around the planet and writes letters to government officials, brandishing academic and military credentials.
Talking Biotech · episode 298
Good Science Information vs Disinformation Feedback Loops Listen
The Genetic Literacy Project is a popular science news website. A diverse set of articles and viewpoints are presented, with original articles and news aggregated from the internet.
Talking Biotech · episode 297
Smart People, Bad Food Choices Listen
Jack Bobo has been studying food, farming and the associated psychology for decades, asking questions about the choices people make around food.
Talking Biotech · episode 296
Turning Plastic Waste Into Vanilla Listen
We have two major problems. Vanilla is mostly produced in a narrow set of unstable economies and the supply chains are especially vulnerable.
Talking Biotech · episode 295
Evidence of Widespread Gene Transfer Listen
Analysis of massive genomic DNA sequence data indicates that gene transfer between similar species actually happened, and did so at a surprising rate.
Talking Biotech · episode 294
Widespread GMOs in Nature Listen
One of the major objections to genetic engineering is that a DNA segment is transferred to the crop, and lands in a somewhat random location.
Talking Biotech · episode 293
Debunking the Disinformation Dozen Listen
Dr. Dan Wilson is a rising star of science communication. His popular YouTube channel Debunk the Funk provides entertaining and evidence-based dissection of issues around science, vaccination and COVID19.
Talking Biotech · episode 292
Peptoids as Therapeutic Tools Listen
Peptides have increasingly emerging roles in cellular signaling and anti-microbial applications. Peptioids are cousins of their active peptide analogs, only synthesized with a durable bond that helps the molecule evade cellular turnover mechanisms.
Talking Biotech · episode 291
Kleptoplasty and a Solar-Powered Animal Listen
A solar-powered animal? There are species of sea slugs that consume algae, then integrate the chloroplasts into their own digestive cells.
Talking Biotech · episode 290
Methylation Clocks, Aging and Disease Listen
The basis of aging and long-term degenerative disease have been formidable questions for scientists. Over the last decade several “methylation clocks” have been devised to examine modifications of DNA that match well with developmental state and disease presentation.
Talking Biotech · episode 289
The GalSafe Pig and Xenotransplantation Listen
Last week’s episode covered Alpha Gal Syndrome, the tick-induced allergy to beef and pork. The same immunological response could also limit a recipient’s access to xenography or xenotransplantation, that is, the introduction of pig and cow tissues and organs for human benefit.
Talking Biotech · episode 288
Alpha Gal Syndrome Listen
You find a tick on your skin and remove it. The next day you eat a sausage and wind up in the emergency room in anaphylaxis.
Talking Biotech · episode 287
Bioluminescence, Antibiotic Resistance, and Science Communication Listen
Today’s podcast is an interview with New Zealander of the Year Dr. Siouxsie Wiles. Dr. Wiles’ program uses bioluminesence as a marker to follow bacterial growth and disease progression.
Talking Biotech · episode 286
Identifying Rare Compounds with A.I. Listen
While genomics approaches have opened a universe of new compounds in plants, the vast majority remain uncharacterized.
Talking Biotech · episode 285
Your DNA Sequence, Benefits and Risks Listen
Your DNA contains all of the information that makes you, you. With increasing understanding of the genetic basis of disease, the information in every cell may help anticipate, correct, or otherwise treat latent medical issues.
Talking Biotech · episode 284
Combating Vaccine Hesitancy Listen
The COVID19 vaccines were produced in record time, an amazing feat. However, additional challenges have been revealed in their distribution.
Talking Biotech · episode 283
Misinformation vs. An Honest Conversation Listen
This week’s podcast is a dissection of another popular podcast that features self-proclaimed experts in genetic engineering (familiarly GMO), and the falsehoods they propagate.
Talking Biotech · episode 282
An App to Identify On-Target Gene Editing Variation Listen
At its core, gene editing works to break gene function by creating errors in a DNA sequence at a specific location.
Talking Biotech · episode 281
COVID19 Testing and Personal Cancer Screenings Listen
One of the major failures of addressing the COVID19 pandemic is the breakdown of testing. The NFL and White House were able to maintain business as usual because of daily, accurate testing.
Talking Biotech · episode 280
Greenpeace Beginnings, and Golden Rice Listen
Dr. Patrick Moore was a founding member of Greenpeace. In the years past its inception he worked tirelessly on ecological issues.
Talking Biotech · episode 279
New Technology to Save Bananas Listen
Bananas and other tropical crops have tremendous value, not just to farmers in the Developing World, but also as products that are enjoyed widely in highly industrialized nations.
Talking Biotech · episode 278
Gene Editing and Recovery from Radiation Listen
Radiation is a natural energy that constantly bombards us. At the same time we have harnessed its power for medical imaging, therapeutics, energy and warfare.
Talking Biotech · episode 277
SARS-CoV2: Immune Response and RNA Vaccines Listen
The story of biotechnology’s response to the pandemic is an amazing one, and we continue coverage of these events as they arise.
Talking Biotech · episode 276
Amazing Products from Algae Listen
Algae efficiently convert carbon dioxide into oils, and they are now being bred to generate a suite of compounds that may be synthesized into fuel and polymers that are the basis of biodegradable plastics.
Talking Biotech · episode 275
Targeting Cancers with Gene Editing Listen
Certain aggressive cancers have profound effects on lifespan and quality of life. Patient prognosis can be grim, and therapies are harsh.
Talking Biotech · episode 274
GE Crops: What do Consumers Really Think? Listen
Consumers have many opinions about food, and are continually bombarded by information from manufacturers to self-proclaimed experts.
Talking Biotech · episode 273
2020 Science Stories Listen
The COVID-19 pandemic overshadowed an incredible year of innovation in biotechnology. Today’s podcast is a simulcast between the Science Facts and Fallacies with Cameron English and Talking Biotech.
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